ESRRA ( estrogen - related receptor alpha ) Stein Kunder R , McDonnell DP

Schematic of nuclear receptor structure and function. ERRa is a member of the nuclear receptor (NR) superfamily of transcription factors and is most closely related to estrogen receptor alpha (ERa). The modular structure of NRs consists of seven (A-F) domains. The A/B region, which harbors activation function 1 (AF-1), is not well-conserved across NRs, but regions C and E are highly conserved and harbor, respectively, the DNA-binding domain (DBD) and ligand-binding domain (LBD). ERRa shares with ERa 68% sequence identity within the DBD and 33% within the LBD. The functional regions of the DBD have been finely mapped. In addition to two zinc finger motifs, this domain contains a Proximal-box (P-box) which determines DNA sequence specificity, and a Dimerization-box (D-box), which part of the dimerization interface.